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NMR EXPERTISE CENTRE

 (15-01-2018) January 2018 marks the official launch of the NMR expertise centre at Ghent University.

The NMR expertise centre is the centre of expertise for structure characterisation and molecular analysis in chemical, biochemical, biomedical and material sciences. The goal is to make NMR infrastructure and knowledge accessible to the entire Research Community and industrial partners.

Do you want to learn what NMR as a technique can mean for you and your research? Then please browse our website or contact us via mail or telephone. See Our state-of-the-art infrastructure, Our team, Our > 20 years of expertise, Our Offer in our business presentation

There are different ways to collaborate with the expertise centre, ranging from open access self-service measurements to dedicated, in-depth analyses performed by the NMR staff. 

Dr. Dieter Buyst - Chief Scientific Officer
Krijgslaan 281 - Building S4bis
B-9000 Gent, Belgium

Email: Dieter.Buyst@ugent.be
Phone: +32-9-264 96 63

Absolute Configuration by VCD

Our joint team of researchers at UGent and UAntwerp have a thorough expertise in Vibrational Optical Activity . The team is equipped with BIOTOOLS ChiralIR-2X VCD Spectrometers.
Within the past few years it has been conclusively demonstrated that VIBRATIONAL CIRCULAR DICHROISM (VCD) is a reliable method for determination of absolute configuration (AC) determinations of chiral molecules. VCD offers a novel alternative to X-ray crystallography, permitting AC determinations on liquids (including oils) and solution-phase samples. VCD requires no derivatization of the sample or growth of a pure single crystal.

On 1st of December 2016, new USP Chapters <782> & <1782> On Vibrational Circular Dichroism became official.

The article demonstrates the usefulness of the VCD technique and how it can address the FDA requirements on proof of AC of the dominant enantiomer and teh enantiomeric excess (EE) to a specified level of purity. Chapter <1782> also explains how VCD can be used for characterization of raw materials for process analytical technology (PAT) during development, synthesis, formulation and final drug product production.

We have a good track record providing services for chemical companies and big (bio)pharma companies.

Read more in the white paper of BioTools inc.

ICP MASS SPECTROMETRY

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) is often deployed for ultra-trace element analysis of biological fluids and tissues and novel approaches, such as ICP-MS/MS, permit extension of the application range. Determination of ultra-trace amounts of metallic elements, e.g. Ti, in body fluids, to detect wear of prostheses, thus becomes possible with quadrupole-based instrumentation. With sample introduction via laser ablation (LA), the 2-dimensional distribution of target elements over a thin section of biological tissue can be visualized. LA-ICP-MS can therefore provide insight in, e.g., the distribution of a Br-containing drug compound across the organs of rat, or the penetration of a Pt-containing chemotherapeutic drug into neoplastic tissue. In whole blood and serum, the isotopic composition of the essential transition metals Fe, Cu and Zn shows natural variation, measurable using state-of-the-art multi-collector ICP-MS.

                           

Read more about our Capabilities and Services at Ghent University is the LA-ICP-MS presentation or contact us.  

Recent research has revealed that the isotopic composition of Cu in serum indicates the severity of liver cirrhosis. As a result, metal isotopic analysis via  MC-ICP-MS as a diagnostic tool is also promising.

Read more ICP Mass Spectrometry or in our joint publication with Janssen Pharmaceutica 

Raman Optical Activity (ROA) for characterisation of biologicals

ROA is a form of polarized Raman spectroscopy that probes molecular chirality. Like circular dichroism (CD), it relies on the fact that chiral molecules respond slightly differently to right- and left-circularly polarized light.

Whereas CD measures optical activity in electronic transitions, ROA (like VCD) measures optical activity in vibrational transitions and hence can provide more structural/stereochemical information since it reports on all 3N-6 fundamental vibrational transitions.

ROA can be applied to a vast range of chiral molecular structures, from small organics to supramolecular structures and large biomolecules.  

Read more 


ChemTech a University Ghent Valorisation unit
Krijgslaan 281 S4 - B-9000 Gent
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