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Poly(2-oxazoline)s for Cancer Drug Delivery

The combination of polymers and pharmaceuticals is enabling the development of advanced drug delivery systems providing high efficacy while minimizing side-effects.Polymer conjugation is applicable to either low molecular weight drugs, peptides or proteins. 

At Biofit Lille 2016 UGent technology: "The versatile polymer platform for the new generation chemotherapy" was presented:

Poly(2-oxazoline)s (abbreviated as PAOx, POx or POZ), set themselves ahead as they display all the required features for the ideal polymer platform for novel biomedical applications. Due to their structural analogy to natural polypeptides, PAOx are biocompatible, exhibit the so-called stealth behavior (they are not recognized by the immune system), and benefit from tunable properties and high functionalization possibilities.

At Ghent University, Belgium, we have develop methods to produce defined PAOx with tunable physicochemical properties (from more hydrophilic than PEG to thermoresponsive), very narrow molar mass distribution (dispersity < 1.10), and high purity (> 99 %).

Read more in the BIOFIT oncology paper and BIOFIT presentation
 

Fullerene Nanoformulations

Fullerene (C60) are of particular interest for biomedical and cosmetic purposes because of their powerful antioxidant and photosensitizer properties. However, their extremely low water solubility limits their bioavailability. At Ghent University a simple, green approach to produce water-soluble fullerene formulations through complexation with water soluble biocompatible polymers such as poly(ethylene glycol), poly(N-vinylpyrrolidone) and poly(2-oxazoline)s.

Technology offer of our proprietary nanoparticles

PAOx Nanoparticles for enhanced mucus penetration

Poly(2-oxazoline) functionalised nanoparticles show enhanced diffusion through mucosal barriers. At University of Reading in the research group of Prof. Khutoryanskiy is was shown that poly(2-oxazoline)s can facilitate the diffusion in porcine gastric mucin dispersions. Poly(2-oxazoline)s (also known as POZ, POx or PAOx) are versatile polymers synthesised at Ghent University in the research group of Prof Hoogenboom, it is a polymer class with numerous pharmaceutical and biomedical applications and has several advantages over PEG; As PAOx based formulations are currently undergoing clinical trials it is expected to gain regulary clearance in the next few years. A series of PAOx polymers were grafted onto the surface of thiolated silica nanoparticles.

This study has shown that poly(2-methyl-2-oxazoline) were significantly more diffuse. This finding provides a new strategy in the design of nanomedicines by surface modification or nanoparticle core construction for enhanced transmucosal drug delivery. PAOx or POZ could be readily grafted to other particle types, such as lipid nanocarriers for enhanced drug delivery, or gold nanoparticles/quantum dots for mucus-penetrating bioimaging.

Contact us to provide you with PAOx tailored to your needs.  

Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier. E. Mansfield, V. de la Rosa, R. Hoogenboom, V. Khutoryanskiy, Biomaterials Science, 4, 1318-1327 (2016)

POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers. E. Mansfield, K. Sillence, A. Williams, V. Khurtoryanskiy, Nanoscale, 7, 13671-13679 (2015)

Poly(2-oxazoline)s: A Polymer Class with Numerous Potential Applications. R. Hoogenboom, Angew. Chem. Int. Ed. 48, 7978-7994 (2009)

PDMS microcapsules


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