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High quality Poly(2-oxazoline)s platform

The Research Group of Prof. R. Hoogenboom has over 30 years of combined scientific excellence in the poly(2-oxazoline) field. The emerging interest in PAOx is based on their highly tunable and beneficial properties, including high stability, high biocompatibility and stealth behavior, i.e. the polymer suppresses interactions with proteins and is therefore not easily recognised by the immune system. In contrast with the current gold standard poly(ethylene glycol) (PEG), PAOx are non-immunogenic, have low viscosity, enable high drug loads and the incorporation of targeting and tracking moieties in a single polymer chain. In 2015, a first polyoxazoline-product entered Phase-I clinical trials.

See our ULTROXA website for more detailed information.   

Versatile Poly(2-oxazoline)s Platform

Contact us  or Ultroxa to obtain tailor made functional PAOx polymers adjusted to your application.

The Excipient of the Future: Poly(2-oxazoline)s

Oral drug administration in the form of tablets, capsules, etc. is still one of the main routes for treating and curing diseases. Poly(2-oxazoline)s are promising candidates as a polymer matrix due to their versatile amphiphilic structure and high physical and chemical stability. However, until now their use as pharmaceutical excipient was impaired by the unavailability of ultra-defined high molar mass poly(2-oxazoline)s. We are seeking partners that are wiling to enhance their API efficacy and bioavailability via novel oral drug formulations.

Plasma Dye Coating to create smart colorimetric materials

Researchers at Ghent University have invented the Plasma Dye Coating (PDC) procedure to covalently immobilize sensing dye molecules on different polymeric surfaces. The PDC dyeing process is a new post fabrication method which can be used to bind the dye molecules to the substrate using high energy plasma surface treatment. By applying this treatment to the surface in the presence of previously adsorbed dye molecules, the formed radical can covalently immobilize the chosen dye on the material surface.
The materials created by this new method have far more economic potential as no more dye leaching occurs, the treatment time is short and is applicable to all polymeric substrates. By choosing a stimuli responsive dye that can detect a specific analyte, sensors can be made which can detect a change in pH (halochromism), temperature (thermochromism), light (photochromism) and solvent (solvatochromism). These sensors can then be used in different fields, e.g. for pH sensitive sensors: smart wound dressing and sensor for spoiled fish.

Read more in the Technology Offer: Plasma Dye Coating: a new and widely applicable method to colour or create sensing Materials 

Nature communications 2018: Plasma dye coating as straightforward and widely applicable procedure for dye immobilization on polymeric materials

The Plasma Dye Coating technology has been shortlisted for the Emeriging Technology Competition 2017 in UK, read more on http://www.chemtech.ugent.be/en/news-events/?year=2017&post=133


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