Division logo


Meet ChemTech at the AMBA 2014 Conference in Ghent at Nov 19-20th - 18/11/2014

Autonomous self-healing material with innovative micro capsules - 14/10/2014

http:// http://www.sim-flanders.be/news/autonomous-self-healing-material-innovative-micro-capsules



The research group Polymer Chemistry of UGent, lead by Prof. Filip De Prez, has developed industrially relevant materials with micro capsules containing innovative glue which can repair damage autonomously in various circumstances. The results were recently published in the renowned journal "Advanced Functional Materials".

Polymeric materials which can heal or repair themselves at freezing temperatures and in summer? It is less far away than we think. Self-healing car lacquers or mobile phone covers are already on the market. Within the SIM program SHE, more specifically the SEPOCOM project, UGent, in collaboration with VUB and the programs industrial partners, has developed the technology. Now they are looking to make the next step towards self-healing of larger applications in ships, aeroplanes, bicycles and wind turbines.

To reach this, micro capsules have been developed containing two industrally relevant chemicals. These micro capsules are very small containers about a tenth of a mm in diameter, containing a liquid. The two used liquids are cheap, stable and non-toxic, and they react very fast when released from the micro capsules, for instance by a scratch or a crack in the material. These two chemicals were selected based on their adhesive strength to glue the crack back together and their ability to flow and mix in the crack. On top of that, the reaction had to be sufficiently fast to slow down or stop further crack formation.

More information about this technology:
UGent press release (in Dutch)
SIM User Forum 2014, where Xander will present his results
• UGent contacts:
o Xander Hillewaere, tel. +32 9 264 44 99, xander.hillewaere@ugent.be
o Prof. Filip Du Prez, tel. +32 9 264 45 03, filip.duprez@ugent.be
• Reference to publication: Hillewaere, Xander; Teixeira, Roberto; Nguyen, Le-Thu; Ramos, José; Rahier, Hubert; Du Prez, Filip, "Autonomous self-healing epoxy thermosets with thiol-isocyanate chemistry", Adv. Funct. Mat. DOI: 10.1002/adfm.201400580 (2014)

Meet ChemTech on September 30th-October 1st 2014 at the Inkjet conference in Dusseldorf. - 12/09/2014

Belgian research teams switch clicks in polymers - 11/09/2014

Thermoset materials acquire thermoplastic properties with the aid of triazolinediones

At Ghent University (Belgium), a new type of so-called ‘click’ chemistry has been introduced. Like with most of click chemistry, it is based on a long-known efficient chemical reaction, which was now also found to be very practical for diverse and demanding applications. In particular, the unique reactivity of the studied 1,2,4-triazoline-3,5-dione (TAD) reagents has been harnessed to reversibly crosslink polyurethanes, or almost any other polymer matrix. At higher temperatures the TAD-induced crosslinks can temporarily open up, giving the thermoset the ability to be reshaped or even extruded like a typical thermoplastic polymer. This is reported in the current issue of Nature Chemistry, in a joint paper by three Ghent research groups led by Filip Du Prez, Veronique Van Speybroeck and Johan Winne.
The TAD reagents used in these new click reactions are quite stable compounds in bulk, but react almost instantaneously with electron rich unsaturated organic compounds. These preferred and orthogonal reaction partners can be easily implemented in polymer chains, resulting in very straightforward macromolecular linking and functionalisation. The TAD-reagents can be clicked to these reaction partners at room temperature without the aid of any catalyst in an almost instantaneous and air- and moisture insensitive manner. In most cases, this ‘dummy proof/sure thing’-reaction will lead to the creation of an irreversible chemical bond. But when the TAD-reaction partner is part of an indole group, a temporary ‘unclick reaction’ can happen at temperatures around 120°C, releasing the original TAD reagent, which can then click to another partner.
With this TAD-based chemistry, a series of click reactions can thus be performed with alternating reaction partners. The reaction sequence can even be ‘programmed’ by choosing suitable alternative substrates. This is a new concept for the field, which was named a ‘transclick’ reaction by the Ghent researchers.
The key feature of the TAD reagents, which enables these new ‘dynamic’ click chemistry applications, is the remarkable reaction kinetics. The energy barriers that are associated with the bond-forming and –breaking steps are very low. This has been verified by advanced calculations. The usual way to ‘make a reaction click’ is to make sure it is a very energetically favorable reaction. This implies that the backward reaction is highly unfavorable, and thus not feasible. “In our search for a suitable reaction partner for ultrafast reacting TADs, all we needed to do was make sure that the reaction was favorable enough to be a true click reaction under ambient conditions, while retaining the ability to reverse the process at a reasonable temperature,” the researchers explain.
What results is a very user-friendly chemical system for performing click reactions. This fact can be further appreciated by another useful feature of the process: TAD molecules are bright red compounds, which are rendered completely colorless after reaction, giving the user an immediate visual feedback. Additionally, the fact that most indole and TAD molecules can be synthesized from bulk chemicals and thus on a large scale, makes this a very interesting platform for industrial partners. The unique reactivity of TAD also opens up possibilities to functionalise or cross-link simple but unreactive raw materials such as natural plant oils. “This is the first time our research group has been spontaneously contacted by several (chemical) companies, interested in performing joint research on one particular type of chemistry for so many different types of applications”, Prof. Du Prez clarifies.





Meet ChemTech on 6 or 7th of October at CPhl Worldwide 2014 Paris - 29/08/2014

CPhI Worldwide is the number one Pharma sourcing event and the world’s leading pharmaceutical networking event. ChemTech will also attend the Pre-connect Congress in the track Excipients & Formulation.

Flanders "CBI-cluster" brings Chemical expertise closer to the biological community - 06/07/2014

Chemtech is co-founder of the Flanders CBI-cluster: CBI “Chemistry to Foster Biology Innovation” is a chemical biology cluster linking the academic chemistry research with the biology community.

This initiative has been coined with the name of Chemistry to Foster Biology Innovation (CBI) and is supported by the organic & medicinal chemistry research groups of the KU Leuven, UAntwerpen, UGent and VUB. The interest of CBI is not limited to classical drug discovery approaches, but CBI will position itself much broader as it will focus on compounds, tools and synthetic methodology to support all aspects of life science research. CBI Provides access to in-depth expertise to open untapped research areas, by bringing chemical expertise closer to the biological community and developing chemical tools to drive biological innovation. The website of CBI is now online: www.cbicluster.be

Meet Chemtech at the American Chemical Society Meeting - 01/07/2014

Meet ChemTech at the 248th American Chemical Society National Meeting in San Francisco (CA) from the 10th to the 14th of August 2014.


New "Expertise at UGent" brochures initiated by ChemTech - 15/06/2014

The flyer of “Advanced Chemical Analysis” clusters 5 research groups providing solutions based on advanced structural and analytical technologies. Both business developers of ChemTech are supporting the Advanced Chemical Analysis team.
The flyer focusing on “Thin Films” presents UGent expertise in deposition technologies such as atomic layer deposition, magnetic sputter deposition and chemical solution deposition from 3 research groups. The Thin Films cluster is supported by 3 business developers of ChemTech, Plateau and Composites@ugent.


ChemTech will attend Knowledge for Growth on May 8th in Ghent - 06/05/2014

On Thursday 8 May 2014, FlandersBio organises the 10th (anniversary!) edition of its annual life sciences convention “Knowledge for Growth” in Ghent
Knowledge for Growth is Europe’s leading regional life sciences convention with > 1.100 participants from
> 325 life sciences companies & organisations. The convention features an elaborate programme of > 30 keynote lectures, an exhibition with > 90 company booths, an area with > 110 research posters, and a Job Fair. ChemTech Lifescience,Business Developer An Van Den Bulcke, will attend for further networking and building knowledge and connections in the Flemish BioTech sector and beyond.

Participation to future conferences - 27/02/2014

Encouraging results in phase II clinical studies for a UGent proprietary vitamin D analogue - 04/02/2014

The UGent proprietary molecule Inecalcitol, a vitamin D analogue, designed and synthesized by the lab of Prof. Pierre De Clercq, has shown positive interim results in a phase 2 clinical trial in Chronic Lymphocytic Leukemia (CLL).
The anti-tumor activity of this compound was originally demonstrated via a collaboration with KULeuven and has led to an exclusive license agreement with Hybrigenics.
In a recent press release Hybrigenics announces that inecalcitol receives positive opinion from EMA for orphan designation in CLL.
The IOF-consortium ChemTech actively follows up on any novel vitamin D developments at Ghent University, sets up new collaborations and searches for license opportunities.

Full press release

ChemTech a University Ghent Valorisation unit
Krijgslaan 281 S4 - B-9000 Gent